Tomoyuki Murano 村野友幸

Publications

Also on ORCID, Google Scholar and researchmap. All papers are open access (CC BY 4.0).

Preprints

Figure from: RFind-sc maps single cells onto biological axes defined by external gene signatures
RFind-sc maps single cells onto biological axes defined by external gene signatures Tomoyuki Murano, Tsuyoshi Miyakawa bioRxiv (2026) paperabstractPDFR packagePython packagecodedata

Introduces a method that places each cell on biological axes defined by external references (expression signatures, gene sets or genetic perturbations), and uses ~1,900 in vivo Perturb-seq knockouts as references to nominate candidate genes for each cell type.

Figure from: Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming
Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming Tomoyuki Murano, Hideo Hagihara, Katsunori Tajinda, Keizo Takao, Yoshihiro Takamiya, Kaoru Katoh, Alfred J. Robison, Mitsuyuki Matsumoto, Masakazu Namihira, Tsuyoshi Miyakawa bioRxiv (2025) paper Published as Nature Communications 17, 5881 (2026)
Figure from: Transdiagnostic characterization of neuropsychiatric disorders by hyperexcitation-induced immaturity
Transdiagnostic characterization of neuropsychiatric disorders by hyperexcitation-induced immaturity Tomoyuki Murano, Hideo Hagihara, Katsunori Tajinda, Mitsuyuki Matsumoto, Tsuyoshi Miyakawa bioRxiv (2018) paper Published as Communications Biology 2, 32 (2019)

Peer-reviewed papers

Figure from: Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming
Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming Tomoyuki Murano, Hideo Hagihara, Katsunori Tajinda, Keizo Takao, Yoshihiro Takamiya, Kaoru Katoh, Alfred J. Robison, Mitsuyuki Matsumoto, Masakazu Namihira, Tsuyoshi Miyakawa Nature Communications 17, 5881 (2026) paperabstractPDFPubMedpreprintcodedataexplainer (Japanese)

A study that modelled electroconvulsive therapy with repeated optogenetic stimulation of the mouse dentate gyrus and revealed that repetitive neuronal activation turns mature neurons into a long-lasting dematured state via nuclear reprogramming.

Media coverage

Social media and video

Figure from: The gene expression patterns as surrogate indices of pH in the brain
The gene expression patterns as surrogate indices of pH in the brain Hideo Hagihara, Tomoyuki Murano, Tsuyoshi Miyakawa Frontiers in Psychiatry 14, 1151480 (2023) paperabstractPDFPubMed

A meta-analysis of 281 human datasets from 11 CNS disorders showing that gene expression associated with lower brain pH is over-represented in disorders such as schizophrenia, bipolar disorder and autism.

Figure from: Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons
Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons Tomoyuki Murano, Ryuichi Nakajima, Akito Nakao, Nao Hirata, Satoko Amemori, Akira Murakami, Yukiyasu Kamitani, Jun Yamamoto, Tsuyoshi Miyakawa PNAS 119(32), e2106830119 (2022) paperabstractPDFPubMedpreprintdata

A study that used calcium imaging and machine learning in freely moving mice to reveal that position, speed and motion direction are independently encoded in populations of dentate gyrus neurons.

Figure from: Expression of progenitor cell/immature neuron markers does not present definitive evidence for adult neurogenesis
Expression of progenitor cell/immature neuron markers does not present definitive evidence for adult neurogenesis Hideo Hagihara, Tomoyuki Murano, Koji Ohira, Miki Miwa, Katsuki Nakamura, Tsuyoshi Miyakawa Molecular Brain 12, 108 (2019) paperabstractPDFPubMed

A review arguing that, because mature neurons can “dematurate” and re-express immature-neuron markers, these markers alone are not definitive evidence of adult neurogenesis in humans.

Figure from: Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders
Transcriptomic immaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders Tomoyuki Murano, Hideo Hagihara, Katsunori Tajinda, Mitsuyuki Matsumoto, Tsuyoshi Miyakawa Communications Biology 2, 32 (2019) paperabstractPDFPubMedpreprintauthor correctionexplainer (Japanese)

A study showing, across 87 disease datasets, that transcriptomic pseudo-immaturity induced by neuronal hyperexcitation is shared by multiple neuropsychiatric disorders, including schizophrenia, Alzheimer's disease and ALS.

Figure from: Transcriptomic immaturity of the hippocampus and prefrontal cortex in patients with alcoholism
Transcriptomic immaturity of the hippocampus and prefrontal cortex in patients with alcoholism Tomoyuki Murano, Hisatsugu Koshimizu, Hideo Hagihara, Tsuyoshi Miyakawa Scientific Reports 7, 44531 (2017) paperabstractPDFPubMed

A study showing immature-like gene expression in the post-mortem hippocampus and prefrontal cortex of patients with alcoholism, with a dominant contribution of fast-spiking neurons.

Conference presentations